Little-known psychedelic drug, 2-5-dimethoxy-4-iodoamphetamine, reduces motivation to take heroin in rats, study finds

Little-known psychedelic drug reduces motivation to take heroin in rats, study finds

Recent research found that the psychedelic drug DOI reduced heroin-seeking behavior in rats by lowering their motivation to obtain heroin. This effect was mediated through 5-HT2A receptors, suggesting DOI’s potential therapeutic role in opioid use disorder treatment.